Recombinant Human IL-11

Catalog Number:AF-200-11

Synonyms:

AGIF (Adipogenesis inhibitory factor)

Description:

IL-11是一种多功能细胞因子，由成纤维细胞，上皮细胞和破骨细胞等基质细胞产生。它在多种组织，包括胸腺，肺，骨，结缔组织和中枢神经系统中表达。IL-11通过促进髓系，红系和巨核细胞祖细胞的生长，对造血起着重要的调节作用。IL-11还调节骨代谢，抑制促炎细胞因子的产生并可防止胃黏膜损伤。重组人IL-11是分子量为19.3 kDa的蛋白，包含179个氨基酸残基。生产过程中的所有试剂均为非动物源性。

AA Sequence:

MPGPPPGPPR VSPDPRAELD STVLLTRSLL ADTRQLAAQL RDKFPADGDH NLDSLPTLAM SAGALGALQL PGVLTRLRAD LLSYLRHVQW LRRAGGSSLK TLEPELGTLQ ARLDRLLRRL QLLMSRLALP QPPPDPPAPP LAPPSSAWGG IRAAHAILGG LHLTLDWAVR GLLLLKTRL

Source:E.coli

Purity:

Greater than 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity:

The ED50 was determined by the dose-dependent stimulation of the proliferation of murine T11 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 10^5 units/mg.