FITC标记的肝细胞生长因子α抗体
产品名称： FITC标记的肝细胞生长因子α抗体
英文名称： Anti-HGF/FITC
产品编号： HZ-1025R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-HGF/FITC Conjugated antibody
FITC标记的肝细胞生长因子α抗体
| 英文名称 | Anti-HGF/FITC |
| 中文名称 | FITC标记的肝细胞生长因子α抗体 |
| 别 名 | HGF alpha; HGFA; F TCF; Hepatocyte growth factor; Fibroblast derived tumor cytotoxic factor; Hepatocyte growth factor precursor; Hepatopoietin A; HPTA; Lung fibroblast derived mitogen; Scatter factor; SF; hepatocyte growth factor alpha-chain; Hepatocyte growth factor alpha chain; HGF_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 免疫学 生长因子和激素 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 54/80kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human HGF alpha |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the lasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. Function: HGF is a potent mitogen for mature parenchymal hepatocyte cells, seems to be an hepatotrophic factor, and acts as growth factor for a broad spectrum of tissues and cell types. It has no detectable protease activity. Subunit: Dimer of an alpha chain and a beta chain linked by a disulfide bond. DISEASE: Defects in HGF are the cause of deafness autosomal recessive type 39 (DFNB39) [MIM:608265]. A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Similarity: Belongs to the peptidase S1 family. Plasminogen subfamily. Contains 4 kringle domains. Contains 1 PAN domain. Contains 1 peptidase S1 domain. Database links: Entrez Gene: 3082 Human Entrez Gene: 282879 Cow Entrez Gene: 15234 Mouse Entrez Gene: 24446 Rat Omim: 142409 Human SwissProt: Q9BH09 Cat SwissProt: Q76BS1 Cow SwissProt: Q867B7 Dog SwissProt: P14210 Human SwissProt: Q08048 Mouse SwissProt: P17945 Rat Unigene: 396530 Human Unigene: 267078 Mouse Unigene: 10468 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 肝细胞生长因子（HGF)是一种多肽生长因子，具有促进包括肝细胞、上皮细胞、内皮细胞、造血细胞等多种类型细胞的生长、迁移和形态发生的作用. 它还参与多种细胞的增殖、迁移,对各类肿瘤的侵袭转移有着重要的诱导作用. HGF除了由肝脏大量产生并释放进入血液，还可从胚胎肺成纤维细胞株中分离得到，因此又称扩散因子（scatter factor）或称肺成纤维细胞衍生生长因子（fibroblast-derived growth factor） |
肝细胞生长因子与原癌基因c-Met受体结合后，通过激活酪氨酸激酶信号级联来调节细胞生长、细胞运动和形态发生。肝细胞生长因子由间充质细胞分泌，主要作用于上皮来源的细胞。它刺激有丝分裂、细胞运动和基质侵袭的能力使它在血管生成、肿瘤发生和组织再生中起着中心作用。它作为一个单一的不活性多肽分泌，并被丝氨酸蛋白酶切割成69-kDaα链和34-kDaβ链。α和β链之间的二硫键产生活性的异二聚体分子。该蛋白属于S1肽酶的Lasmin原亚科，但没有可检测的蛋白酶活性。该基因的选择性剪接产生了编码不同亚型的多个转录变体。[ RefSeq，JUL 2008 ]提供。