FITC标记的磷酸化乳腺癌易感基因1抗体
产品名称： FITC标记的磷酸化乳腺癌易感基因1抗体
英文名称： Anti-Phospho-BAP1 (Ser592)/FITC
产品编号： HZ-3051R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-Phospho-BAP1 (Ser592)/FITC Conjugated antibody
FITC标记的磷酸化乳腺癌易感基因1抗体
| 英文名称 | Anti-Phospho-BAP1 (Ser592)/FITC |
| 中文名称 | FITC标记的磷酸化乳腺癌易感基因1抗体 |
| 别 名 | BAP1 (Phospho-Ser592); BAP1 (Phospho-S592); p-BAP1 (Ser592); p-BAP1 (S592); BAP 1; Bap1; BAP1_HUMAN; BRCA 1 associated protein 1; BRCA1 associated protein 1; BRCA1-associated protein 1; Cerebral protein 13; Cerebral protein 6; DKFZp686N04275; FLJ35406; FLJ37180; HUCEP 13; Hucep 6; HUCEP13; Hucep6; KIAA0272; TPDS; Ubiquitin carboxy terminal hydrolase; Ubiquitin carboxyl terminal hydrolase BAP 1; Ubiquitin carboxyl terminal hydrolase BAP1; Ubiquitin carboxyl-terminal hydrolase BAP1; UCHL2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 肿瘤 免疫学 信号转导 转录调节因子 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Rat, Dog, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 81kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from human BAP1 around the phosphorylation site of Ser592 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC for BRCA1-associated genome surveillance complex. This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complex. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants have been described for this gene but only some have had their full-length natures identified. Transcript Variant: This variant (BRCA1a') uses different splice site in the 5' UTR when compared to variant BRCA1a. It encodes the full-length BRCA1 protein (isoform 1) which is also known as p220. Variants BRCA1a and BRCA1b also encode the full-length BRCA1 protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. Function: Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Acts as a tumor suppressor. Subunit: Component of the PR-DUB complex, at least composed of BAP1 and ASXL1. Interacts with BRCA1 (via the RING finger). Interacts (via HBM-like motif) with HCFC1. Subcellular Location: Cytoplasm. Nucleus. Note=Mainly nuclear. Binds to chromatin. Tissue Specificity: Highly expressed in testis, placenta and ovary. Expressed in breast. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the peptidase C12 family. BAP1 subfamily. Database links: Entrez Gene: 8314 Human Entrez Gene: 306257 Rat Omim: 603089 Human SwissProt: Q92560 Human SwissProt: D3ZHS6 Rat Unigene: 106674 Human Unigene: 3382 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. BRCA1基因是最早被发现的乳腺癌易感基因其突变和家族性乳腺癌、卵巢癌的发病有关 |
该基因编码核磷蛋白，在维持基因组稳定性中起作用，并起肿瘤抑制作用。编码的蛋白质与其他肿瘤抑制因子、DNA损伤传感器和信号转导子一起形成BALCA1相关基因组监测复合物的BASC大的多亚基蛋白复合物。该基因产物与RNA聚合酶II相关，并通过C-末端结构域，还与组蛋白脱乙酰基酶复合物相互作用。因此，该蛋白在转录、双链断裂的DNA修复和重组中起作用。该基因的突变约占遗传性乳腺癌的40%，遗传性乳腺癌和卵巢癌的80%以上。选择性剪接在调控该基因的亚细胞定位和生理功能方面起着重要作用。许多选择性剪接转录变体已被描述为这个基因，但只有一些已经有他们的全长性质鉴定。转录变体：此变体（BRCA1A’）在5′UTR中使用不同的剪接位点，而与变体BRCA1A相比，它编码全长BRCA1蛋白（异构体1），也称为P220。变体BRCA1A和BRCA1B也编码全长BRCA1蛋白。出版物注释：这个RefSEQ记录包括该基因可用的出版物的一个子集。请参阅Entrez Gene记录以访问其他出版物。