FITC标记的肿瘤/睾丸抗原2.3抗体
产品名称: FITC标记的肿瘤/睾丸抗原2.3抗体
英文名称: Anti-BAGE3/FITC
产品编号: HZ-9115R-FITC
产品价格: null
产品产地: 中国/上海
品牌商标: HZbscience
更新时间: 2023-08-17T10:24:20
使用范围: IF=1:50-200
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Rabbit Anti-BAGE3/FITC Conjugated antibody
FITC标记的肿瘤/睾丸抗原2.3抗体
产品编号 | bs-9115R-FITC |
英文名称 | Anti-BAGE3/FITC |
中文名称 | FITC标记的肿瘤/睾丸抗原2.3抗体 |
别 名 | B melanoma antigen family member 3; B melanoma antigen 3; BAGE3; BAGE3_HUMAN; Cancer/testis antigen 2.3; Cancer/testis antigen family 2 member 3; CT2.3. |
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
研究领域 | 肿瘤 细胞生物 免疫学 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, |
产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 10kDa |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human BAGE3 |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
产品介绍 | background: Unknown. Candidate gene encoding tumor antigens. Members of the BAGE gene family encode antigens that are recognized by cytotoxic T lymphocytes and are also known as CT (cancer/testis) antigens. Generated by juxtacentromeric shuffling of the MLL3 gene, the ancestral BAGE gene was expanded by acrocentric exchanges and/or juxtacentromeric movements.Generally, BAGE proteins are silent in all normal tissues with the exception of testis. BAGE2 and BAGE 3 (B melanoma antigen 2 and 3, respectively), also known as Cancer/testis antigen 2.2 and 2.3 (respectively), are 109 amino acid secreted proteins that are expressed in 22% of melanomas, lung and bladder carcinomas, and are also expressed in normal testis tissue. Like the genes encoding MAGE proteins, BAGE genes are most likely silenced by DNA methylation and/or chromatin compaction in normal tissues other than testis. Function: Unknown. Candidate gene encoding tumor antigens. Subcellular Location: Secreted Tissue Specificity: Not expressed in normal tissues except in testis. Expressed in melanoma, bladder and lung carcinomas. Similarity: Belongs to the BAGE family. Database links: UniProtKB/Swiss-Prot: Q86Y29.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
未知的。编码肿瘤抗原的候选基因。BAGE基因家族的成员编码由细胞毒性T淋巴细胞识别的抗原,也称为CT(癌/睾丸)抗原。通过MLL3基因的等位基因混洗,祖先的BEG基因通过近端着丝粒交换和/或左右着丝粒运动而扩展。一般而言,除了睾丸以外,所有的正常组织中的BEP蛋白都是沉默的。BAGE2和BAGE 3(B黑色素瘤抗原2和3),也称为癌/睾丸抗原2.2和2.3(分别)是109个氨基酸分泌蛋白,在22%个黑色素瘤、肺和膀胱癌中表达,并且在正常睾丸组织中也表达。与编码MAGE蛋白的基因一样,在睾丸以外的正常组织中,BEG基因最有可能被DNA甲基化和/或染色质压实所沉默。