FITC标记的突触结合蛋白1样2抗体
产品名称： FITC标记的突触结合蛋白1样2抗体
英文名称： Anti-SCFD1/FITC
产品编号： HZ-17280R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-SCFD1/FITC Conjugated antibody
FITC标记的突触结合蛋白1样2抗体
| 英文名称 | Anti-SCFD1/FITC |
| 中文名称 | FITC标记的突触结合蛋白1样2抗体 |
| 别 名 | C14orf163; Chromosome 14 open reading frame 163; RA410; Scfd1; SCFD1_HUMAN; Sec1 family domain containing 1; Sec1 family domain-containing protein 1; SLY1; SLY1 homolog; Sly1p; STXBP1L2; Syntaxin binding protein 1 like 2; Syntaxin-binding protein 1-like 2; Vesicle transport related protein. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, Ferret, Rhesus monkey, Gorilla, Orangutan, Elephant |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 72kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SCFD1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: SCFD1 is a 642 amino acid protein that belongs to the STXBP/unc-18/SEC1 family. Phosphorylated upon DNA damage, probably by Atm or ATR, SCFD1 is involved in vesicular transport between the endoplasmic reticulum (ER) and the Golgi. The SCFD1 protein plays a role in SNARE-pin assembly and Golgi to ER retrograde transport via its interaction with COG4. The SCFD1 protein also binds Syntaxin 5. The SCFD1 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, mosquito, Drosophila, C.elegans, S.pombe, S.cerevisiae, K.lactis, E.gossypii, M.grisea, N.crassa, A.thaliana and rice, and maps to human chromosome 14q12. Deletion of a region of chromosome 14 that contains BF-1, PKC ? SCFD1, Cochlin and SG2NA genes, is responsible for a condition resulting in severe mental retardation, epilepsy, microcephaly and Rett-like features. Function: Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi. Subcellular Location: Cytoplasm. Endoplasmic reticulum membrane. Golgi apparatus > Golgi stack membrane. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the STXBP/unc-18/SEC1 family. Database links: Entrez Gene: 100140328 Cow Entrez Gene: 480281 Dog Entrez Gene: 23256 Human Entrez Gene: 76983 Mouse Entrez Gene: 54350 Rat SwissProt: Q8WVM8 Human SwissProt: Q8BRF7 Mouse SwissProt: Q62991 Rat Unigene: 369168 Human Unigene: 216511 Mouse Unigene: 10761 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
SCFD1是属于STXBP/UNC-18/SEC1家族的642个氨基酸。SCFD1可能通过Atm或ATR在DNA损伤时磷酸化，参与内质网（ER）和高尔基体之间的囊泡运输。ScFD1蛋白通过与COG4的相互作用在SNARE PIN组装和Golgi到ER逆行转运中起作用。SCDF1蛋白还结合SytRunin 5。SCFD1基因在黑猩猩、狗、奶牛、小鼠、大鼠、鸡、斑马鱼、蚊子、果蝇、秀丽线虫、果蝇、酿酒酵母、乳链球菌、棉蚜、稻瘟病菌、稻瘟病菌、拟南芥、拟南芥、稻瘟病菌、稻瘟病菌和大米中均存在保守性，并定位于人染色体14q12。缺失含有BF-1、PKC的14号染色体的区域？SCFD1、Cochlin和SG2NA基因是导致严重智力低下、癫痫、小头畸形和Rett样特征的原因。