Human Growth Factors & Cytokines
Recombinant Human IL-21





 





		Synonyms :
none.



		Description :
IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation.  Its action generally enhances antigen-specific responses of immune cells.  The biological effects of IL-21 include induction of differentiation of T-cells-stimulated B-cells into plasma cells and memory B-cells, stimulation (in conjuction) with IL-4 of IgG production, and induction of apoptotic effects in na?ve B-cells and stimulated B-cells in the absence of T-cell signaling.  Additionally, IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells.  IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the gamma chain (γc) found in other cytokine receptors including IL-2, IL-4, IL-7, IL-9 and IL-15.  The IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3.  Recombinant human IL-21 is a 15.4 kDa protein consisting of 132 amino acid residues.



		Catalog #:
200-21



		Source :
E.coli



		Purity :
Greater than 98% by SDS-PAGE gel and HPLC analyses.



		Endotoxin Level :
Endotoxin level is less than 0.1 ng per μg (1EU/μg).



		Biological Activity :
Assay #1:Determined by its ability to proliferate activated B cells. 

 

Assay #2:Determined by its ability to induce human CD40L-activated na?ve B cells to undergo Ig isotype switching to IgG, using an IL-21 concentration of 50 ng/ml. Maximal activity was achieved after approximately five cell divisions.

Avery, D.T. et. al. (2008) J. Immunol. 181, 1767-1779.


Selected References :
Selected List of References Citing This PeproTech Product



                AA Sequence :
MQDRHMIRMR QLIDIVDQLK NYVNDLVPEF LPAPEDVETN CEWSAFSCFQ KAQLKSANTG NNERIINVSI KKLKRKPPST NAGRRQKHRL TCPSCDSYEK KPPKEFLERF KSLLQKMIHQ HLSSRTHGSE DS 



		PubMed Link :
IL-21


Country of Origin :
USA
















        Size A
2μg
$80 
 


 



        Size B
10μg
$195 
 


 



        Size C
1mg
$5200 
 


 















Special 
                    Sizes: 
 Many products can be ordered in custom sizes. Please click here to contact Peprotech with your request.





Usage:
For Research Use Only.  Not for use in diagnostic or therapeutic procedures.