FITC标记的钙依赖分泌激活蛋白1抗体
产品名称： FITC标记的钙依赖分泌激活蛋白1抗体
英文名称： Anti-CAPS1/FITC
产品编号： HZ-11812R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围：
上海沪震实业有限公司
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Rabbit Anti-CAPS1/FITC Conjugated antibody
| FITC标记的钙依赖分泌激活蛋白1抗体 |
| 英文名称 | Anti-CAPS1/FITC |
| 中文名称 | FITC标记的钙依赖分泌激活蛋白1抗体 |
| 别 名 | Cadps; CADPS1; Calcium dependent secretion activator 1; Calcium-dependent activator protein for secretion 1; Calcium-dependent secretion activator 1; Caps; CAPS-1; rCAPS; CAPS1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 神经生物学 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 153kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CAPS1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described. [provided by RefSeq, Aug 2008] Function: CAPS1 (Ca2+-dependent activator protein for secretion) belongs to the CAPS/Cadps family which consists of two members, CAPS1 and CAPS2. The CAPS family proteins are involved in the secretion of different secretory substances in developing and postnatal brains. In addition CAPS1 regulates catecholamine release from neuroendocrine cells and is expressed predominantly in the brain. Subunit: Homodimer. Interacts with RASL10B. Interacts with the dopamine receptor DRD2. Subcellular Location: Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Note=Membrane-associated to vesicles. Strongly enriched in synaptic fractions. Preferentially binds to DCVs but not to SVs. Binds phosphoinosides, with a strong selectivity for PtdIns(4,5)P2 over PtdIns(3,4,5)P3. Probably localizes to different vesicles compared to CADPS2. Tissue Specificity: Specifically expressed in neural and endocrine secretory tissues. Expressed in brain and pancreas and at low level in heart. Also expressed in fetal heart, cerebellum, cerebral cortex, medulla, occipital pole, frontal and temporal lobes, and putamen, as well as weak expression in spinal cord. Similarity: Contains 1 C2 domain. Contains 1 MHD1 (MUNC13 homology domain 1) domain. Contains 1 PH domain. Database links: Entrez Gene: 8618 Human Entrez Gene: 27062 Mouse Entrez Gene: 26989 Rat Omim: 604667 Human SwissProt: Q9ULU8 Human SwissProt: Q80TJ1 Mouse SwissProt: Q62717 Rat Unigene: 260881 Mouse Unigene: 88197 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
这个新基因在神经内分泌encodes /外围膜蛋白与特异性cytosolic required for the of exocytosis Ca2+排泄分泌vesicles上调。茶叶蛋白的行为在exocytosis实习，在ATP依赖性吸的是必要的，involves of which the合成磷脂酰肌醇4,5 -二磷酸（PtdIns（4,5）的P2）。at this has been观察选择性剪接位点和三isoforms是distinct variants，编码，描述的程序办理。[提供]序列模式，2008年8月