SNCA monoclonal antibody, clone 2A7
产品名称： SNCA monoclonal antibody, clone 2A7
英文名称： SNCA monoclonal antibody, clone 2A7
产品编号： MAB5383
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against recombinant SNCA.
- Immunogen:
- Recombinant His fusion protein corresponding to human SNCA.
- Host:
- Mouse
- Theoretical MW (kDa):
- 15
- Reactivity:
- Human, Mammals
- Form:
- Liquid
- Isotype:
- IgG1
- Storage Buffer:
- In ascites (5 mM sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1:10000)
Immunofluorescence (1:1000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- alpha-Synuclein and neuronal cell death.
Cookson MR.Mol Neurodegener. 2009 Feb 4;4:9.
- 2.
- Alpha-synuclein locus duplication as a cause of familial Parkinson's disease.
Chartier-Harlin MC, Kachergus J, Roumier C, Mouroux V, Douay X, Lincoln S, Levecque C, Larvor L, Andrieux J, Hulihan M, Waucquier N, Defebvre L, Amouyel P, Farrer M, Destee A.Lancet. 2004 Sep 25-Oct 1;364(9440):1167-9.
- 3.
- Causal relation between alpha-synuclein gene duplication and familial Parkinson's disease.
Ibanez P, Bonnet AM, Debarges B, Lohmann E, Tison F, Pollak P, Agid Y, Durr A, Brice A.Lancet. 2004 Sep 25-Oct 1;364(9440):1169-71.
- Applications
- Western Blot
- Western Blot of SNCA monoclonal antibody, clone 2A7 (Cat # MAB5383) on recombinant SNCA (left lane) and crude extract of mouse brain (right lane, courtesy Rogan Tinsley, Howard Florey Institute, University of Melbourne).
- Immunofluorescence
- Mixed neuron-glial cultures stained with SNCA monoclonal antibody, clone 2A7 (Cat # MAB5383), our monoclonal antibody to SNCA (red) and chicken polylclonal antibody to MAP2 (green).
The SNCA monoclonal antibody stains vesicular structures the perikarya and processes of the neurons in this image.
Note that some of the neuronal perikarya contain much more alpha-synuclein than others.
The blue channel shows the localization of DNA.
- Entrez GeneID:
- 6622
- Protein Accession#:
- L08850
- Gene Name:
- SNCA
- Gene Alias:
- MGC110988,NACP,PARK1,PARK4,PD1
- Gene Description:
- synuclein, alpha (non A4 component of amyloid precursor)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq
- Other Designations:
- OTTHUMP00000161559,OTTHUMP00000161561,alpha synuclein,alpha-synuclein,alpha-synuclein, isoform NACP140,non A-beta component of AD amyloid,non A4 component of amyloid
- Interactome
- Gene Pathway
- Related Disease
- Alcoholism
- Alzheimer Disease
- Alzheimer disease
- Amphetamine-Related Disorders
- Association Learning
- Attention
- Cardiovascular Diseases
- Chromosome Breakage
- Cognition Disorders
- Color Perception
- Cystic Fibrosis
- Cystic fibrosis
- Dementia
- Diabetes Complications
- Disease Progression
- Disease Susceptibility
- Essential Tremor
- Essential tremor
- Genetic Predisposition to Disease