FITC标记的MSH5蛋白抗体
产品名称： FITC标记的MSH5蛋白抗体
英文名称： Anti-MSH5/FITC
产品编号： HZ-17852R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-MSH5/FITC Conjugated antibody
FITC标记的MSH5蛋白抗体
| 英文名称 | Anti-MSH5/FITC |
| 中文名称 | FITC标记的MSH5蛋白抗体 |
| 别 名 | DKFZp434C1615; G7; hMSH5; MGC2939; MSH 5; MSH5; MSH5_HUMAN; mutS (E. coli) homolog 5; mutS homolog 5; mutS homolog 5 (E. coli); MutS protein homolog 5; MutSH5; NG23; OTTHUMP00000029187; OTTHUMP00000029188. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, Xenopus laevis, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 93kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MSH5 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms hetero-oligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 6 open reading frame 26 (C6orf26) gene. [provided by RefSeq, Feb 2011] Function: Involved in meiotic recombination. Facilitate crossovers between homologs during meiosis. Subunit: Heterooligomer of MSH4 and MSH5. Interacts with HJURP. Tissue Specificity: Ubiquitous, but highly expressed in testis, and thymus. Similarity: Belongs to the DNA mismatch repair mutS family. Database links: Entrez Gene: 100139295 Cow Entrez Gene: 474848 Dog Entrez Gene: 100050672 Horse Entrez Gene: 4439 Human Entrez Gene: 715494 Monkey Entrez Gene: 17687 Mouse Entrez Gene: 100270818 Pig Entrez Gene: 294252 Rat Omim: 603382 Human SwissProt: O43196 Human SwissProt: Q9QUM7 Mouse SwissProt: Q6MG62 Rat Unigene: 647011 Human Unigene: 24192 Mouse Unigene: 44043 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因编码参与DNA错配修复和减数分裂重组的MUTS家族成员。该蛋白类似于酿酒酵母蛋白，在减数分裂过程中参与分离保真度和交叉事件。该蛋白在促进电离辐射诱导的细胞凋亡中起重要作用。该蛋白质与该家族的另一成员形成杂寡聚物，MUTS同源物4。该基因多态性已与多种人类疾病相关，包括IgA缺乏、常见可变免疫缺陷和卵巢早衰。选择性剪接导致多个转录变体。在该基因与下游染色体6开放阅读框26（C6OF26）基因之间也存在通读转录。[ RefSeq，FEB 2011 ]提供