FITC标记的基质交感分子2抗体
产品名称： FITC标记的基质交感分子2抗体
英文名称： Anti-STIM2/FITC
产品编号： HZ-12826R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-STIM2/FITC Conjugated antibody
FITC标记的基质交感分子2抗体
| 英文名称 | Anti-STIM2/FITC |
| 中文名称 | FITC标记的基质交感分子2抗体 |
| 别 名 | FLJ39527; KIAA1482; STIM 2; STIM2; STIM2_HUMAN; stromal interaction molecule 2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 83kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 2mg/1ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human STIM2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene is a member of the stromal interaction molecule (STIM) family and likely arose, along with related family member STIM1, from a common ancestral gene. The encoded protein functions to regulate calcium concentrations in the cytosol and endoplasmic reticulum, and is involved in the activation of plasma membrane Orai Ca(2+) entry channels. This gene initiates translation from a non-AUG (UUG) start site. A signal peptide is cleaved from the resulting protein. Multiple transcript variants result from alternative splicing. [provided by RefSeq, Dec 2009] Function: Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. Subcellular Location: Endoplasmic reticulum membrane. Dynamically translocates from a uniform endoplasmic reticulum distribution to punctual endoplasmic reticulum-plasma membrane junctions in response to decrease in endoplasmic reticulum Ca(2+) concentration. Tissue Specificity: Expressed in all tissues and tumor cell lines examined. Post-translational modifications: Glycosylated. Phosphorylated predominantly on Ser residues. Similarity: Contains 1 EF-hand domain. Contains 1 SAM (sterile alpha motif) domain. Database links: Entrez Gene: 57620 Human Entrez Gene: 116873 Mouse Entrez Gene: 117087 Rat Omim: 610841 Human SwissProt: Q9P246 Human SwissProt: P83093 Mouse Unigene: 726179 Human Unigene: 265985 Mouse Unigene: 162277 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因是基质相互作用分子（STIM）家族的成员，可能与相关家族成员STIM1一起起源于一个共同的祖先基因。该编码蛋白具有调节胞浆和内质网钙浓度的功能，并参与细胞膜Orai Ca(2+)进入通道的激活。该基因启动从非AUG（UUG）起始位点的翻译。从所得到的蛋白质裂解信号肽。多个转录变异源于选择性剪接。[