FITC标记的酪氨酸蛋白激酶受体A7抗体
产品名称： FITC标记的酪氨酸蛋白激酶受体A7抗体
英文名称： Anti-EphA7/FITC
产品编号： HZ-7034R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-EphA7/FITC Conjugated antibody
| FITC标记的酪氨酸蛋白激酶受体A7抗体 |
| 英文名称 | Anti-EphA7/FITC |
| 中文名称 | FITC标记的酪氨酸蛋白激酶受体A7抗体 |
| 别 名 | Cek 11; Developmental kinase 1; EBK; EHK-3; EHK3; EK11; Embryonic brain kinase; Eph homology kinase 3; Eph receptor A7; EPH-like kinase 11; EphA7; EPHA7_HUMAN; Ephrin receptor Eph A7; Ephrin type A receptor 7; Ephrin type-A receptor 7; hEK11; MDK 1; Receptor protein tyrosine kinase HEK 11; Tyrosine protein kinase receptor EHK 3. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 心血管 细胞生物 免疫学 神经生物学 信号转导 激酶和磷酸酶 细胞膜受体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 50/107kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human EphA7 (200-250aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families). Receptor for members of the ephrin-A family. Binds to ephrin-A1, ephrin-A2, ephrin-A3, ephrin-A4 and ephrin-A5. Function: ’Receptor tyrosine kinase which binds promiscuouslyGPI-anchored ephrin-A family ligands residing on adjacent cells,leading to contact-dependent bidirectional signaling intoneighboring cells. The signaling pathway downstream of the receptoris referred to as forward signaling while the signaling pathwaydownstream of the ephrin ligand is referred to as reversesignaling. Among GPI-anchored ephrin-A ligands, EFNA5 is acognate/functional ligand for EPHA7 and their interaction regulatesbrain development modulating cell-cell adhesion and repulsion. Hasa repellent activity on axons and is for instance involved in theguidance of corticothalamic axons and in the proper topographicmapping of retinal axons to the colliculus. May also regulate braindevelopment through a caspase(CASP3)-dependent proapoptoticactivity. Forward signaling may result in activation of componentsof the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 ANDMAPK3 which are phosphorylated upon activation of EPHA7. Isoform 4which lacks the kinase domain may regulate isoform 1 adhesiveproperties. Subunit: Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity). Interacts (via PDZ-binding motif) with GRIP1 and PICK1 (via PDZ domain). Subcellular Location: Cell membrane (Probable); Single-pass type I membrane protein (Probable). Tissue Specificity: Widely expressed in embryo. In adult, expression restricted to hippocampus, testis and spleen. Post-translational modifications: Phosphorylated. Isoform 4 inhibits isoform 1 phosphorylationand may regulate its function in adhesion. Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. Contains 1 Eph LBD (Eph ligand-binding) domain. Contains 2 fibronectin type-III domains. Contains 1 protein kinase domain. Contains 1 SAM (sterile alpha motif) domain. Database links: Entrez Gene: 2045 Human Entrez Gene: 13841 Mouse Entrez Gene: 171287 Rat Omim: 602190 Human SwissProt: Q15375 Human SwissProt: Q61772 Mouse SwissProt: P54759 Rat Unigene: 73962 Human Unigene: 257266 Mouse Unigene: 10181 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
蛋白激酶是将磷酸基团从磷酸盐供体（通常是ATP的磷酸）转移到底物蛋白中的受体氨基酸的酶。通过这一基本机制，蛋白激酶介导了真核细胞中的大部分信号转导，调节细胞代谢、转录、细胞周期进程、细胞骨架重排和细胞运动、细胞凋亡和分化。蛋白激酶家族是500多种基因产物，是真核生物中最大的蛋白质家族之一。根据它们的酪氨酸（PTK）或丝氨酸/苏氨酸激酶催化域的序列比较，该家族已被分为8大类。酪氨酸激酶（TK）组主要参与细胞间的相互作用，如分化、粘附、运动和死亡。目前约有90个TK基因测序，58个是受体蛋白TK（例如EGFR、EFR、FGFR、PDGFR、Trk和VEGFR家族），和胞浆TK的32（例如ABL、FAK、JAK和SRC家族）。
Errin A家族成员的受体。与Errin -A1、Errin -A2、Errin -A3、Errin -A4和Errin -A5结合。